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14-Cinnamoyloxycodeinone as a hydroxycodeinone derivative, which is a 14-cinnamate ester. The effect is similar to oxycodone and fentanyl, while it's Molecular Formula is C27H25NO5.
The CAS number of 14-Cinnamoyloxycodeinone is 751-01-9.
More information of 14-Cinnamoyloxycodeinone 751-01-9 are:
|
Synonyms |
Codeinone,14-hydroxy-,cinnamate;14-Hydroxycodeinone cinnamate;14-Cinnamoyloxycodeinone; |
|
CAS Number |
751-01-9 |
|
Molecular Formula |
C27H25NO5 |
|
Molecular Weight |
443.53 |
|
Density |
1.36g/cm3 |
|
Boiling Point |
617.2°Cat760mmHg |
|
Flash Point |
327.1°C |
|
PSA |
65.07000 |
|
LogP |
3.02640 |
|
Pka |
6.14±0.40(Predicted) |
14-Cinnamoyloxycodeinone is the most potent example in a series of opiate analgesic drugs discovered in the 1960s, with > ×100 times the potency of morphine. In 14-phenylalkyloxy derivatives maximal analgesic potency was found in 14-cinnamoyloxycodeinone. 14-Cinnamoyloxycodeinone is the most potent example in a series of opiate analgesic drugs.
InChI:InChI=1/C27H25NO5/c1-28-15-14-26-23-18-9-10-20(31-2)24(23)32-25(26)19(29)12-13-27(26,21(28)16-18)33-22(30)11-8-17-6-4-3-5-7-17/h3-13,21,25H,14-16H2,1-2H3/b11-8+/t21-,25+,26+,27-/m1/s1
Articles related to 3-Phenylpropenoic acid 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methyl-6-oxomorphinan-14-yl ester:
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Article |
Source |
| Some pharmacological studies with 14‐cinnamoyloxycodeinone |
W. R. Buckett Published 1 November 1965 Chemistry Journal of Pharmacy and Pharmacology There is a wide separation between LD50 values by intravenous and by other routes for 14-cinnamoyloxycodeinone but not for morphine. This may be due in part to the high lipid solubility of the ester facilitating rapid penetration into the central nervous system. |
| Some pharmacological studies with 14-ciimamoyloxycodeinone | RM LD50, LD Cinnamoyloxycodeinone - Journal of Pharmacy and …, 1965 |
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