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pd_meltingpoint:240-245 °C (dec.)
Appearance:Tan Solid
Purity:99%
|
Chemical Properties |
Tan Solid |
|
Uses |
Genistein intermediate. |
|
Preparation |
Preparation by reaction of p-hydroxyphenyl-acetonitrile with phloroglucinol (Hoesch reaction) (58%). |
InChI:InChI=1/C14H12O5/c15-9-3-1-8(2-4-9)5-11(17)14-12(18)6-10(16)7-13(14)19/h1-4,6-7,15-16,18-19H,5H2
A microwave-promoted synthesis of polyhy...
Soybean isoflavonoids, 7,4'-dihydroxyiso...
Starting from previous structure-activit...
As part of a program focused on the deve...
The invention provides a novel platform ...
Development and scale-up of the syntheti...
We describe 2,4,4′,6-tetrahydroxydeoxybe...
3,5-dihydroxyphenol
4-hydroxyphenylacetate
2,4,4',6-tetrahydroxydeoxybenzoin
| Conditions | Yield |
|---|---|
|
With
boron trifluoride diethyl etherate;
at 0 ℃;
for 5h;
|
83% |
|
With
boron trifluoride diethyl etherate;
In
various solvent(s);
at 90 ℃;
for 0.0666667h;
microwave irradiation;
|
67% |
|
With
boron trifluoride diethyl etherate;
at 85 ℃;
for 1.5h;
|
|
|
3,5-dihydroxyphenol; 4-hydroxyphenylacetate;
With
boron trifluoride diethyl etherate;
at 70 - 80 ℃;
Heating / reflux;
In
DMF (N,N-dimethyl-formamide);
|
|
|
With
boron trifluoride diethyl etherate;
at 85 ℃;
for 1.5h;
|
3,5-dihydroxyphenol
4-cyanomethylphenol
2,4,4',6-tetrahydroxydeoxybenzoin
| Conditions | Yield |
|---|---|
|
3,5-dihydroxyphenol; 4-cyanomethylphenol;
With
hydrogenchloride;
In
acetic acid methyl ester;
at 5 - 20 ℃;
for 19h;
With
sodium hydroxide; ethanol; water;
In
ethyl acetate;
at 75 - 101 ℃;
for 7h;
pH=4.0;
Product distribution / selectivity;
Heating / reflux;
|
78.6% |
|
With
hydrogenchloride;
In
diethyl ether;
at 0 ℃;
for 24h;
|
72% |
|
With
bis(trifluoromethanesulfonyl)amide;
In
various solvent(s);
at 90 ℃;
for 0.0666667h;
microwave irradiation;
|
65% |
|
3,5-dihydroxyphenol; 4-cyanomethylphenol;
With
hydrogenchloride;
In
ethyl acetate;
at 5 - 20 ℃;
for 19h;
With
sodium hydroxide; ethanol; water;
In
ethyl acetate;
at 75 - 101 ℃;
for 7h;
pH=4.0;
Product distribution / selectivity;
Heating / reflux;
|
64% |
|
3,5-dihydroxyphenol; 4-cyanomethylphenol;
With
hydrogenchloride; zinc(II) chloride;
In
diethyl ether;
at 0 - 20 ℃;
With
water;
In
methanol;
for 5h;
Reflux;
|
61.9% |
|
With
hydrogenchloride;
In
1,4-dioxane;
|
58% |
|
3,5-dihydroxyphenol; 4-cyanomethylphenol;
With
hydrogenchloride; aluminum (III) chloride;
In
diethyl ether;
at 0 ℃;
for 6h;
Inert atmosphere;
Large scale;
With
water;
for 2h;
Reflux;
Large scale;
|
54% |
|
3,5-dihydroxyphenol; 4-cyanomethylphenol;
With
hydrogenchloride; aluminum (III) chloride; calcium chloride;
In
diethyl ether;
at 0 ℃;
for 6h;
Inert atmosphere;
With
water;
In
diethyl ether;
for 2h;
Reflux;
Inert atmosphere;
|
54% |
|
3,5-dihydroxyphenol; 4-cyanomethylphenol;
With
hydrogenchloride; zinc(II) chloride;
In
diethyl ether;
at 0 - 20 ℃;
With
sulfuric acid; water;
In
diethyl ether;
for 2h;
Reflux;
|
54% |
|
With
hydrogenchloride; water; zinc(II) chloride;
at 0 ℃;
Reflux;
|
53% |
|
With
hydrogenchloride;
In
diethyl ether;
for 24h;
|
46.5% |
|
With
hydrogenchloride; diethyl ether;
at 0 ℃;
Erhitzen des entstandenen Imidhydrochlorids mit Wasser;
|
|
|
With
hydrogenchloride; zinc(II) chloride;
at 0 ℃;
|
3,5-dihydroxyphenol
4-cyanomethylphenol
4-hydroxyphenylacetate
4,6-Dihydroxy-2-(4-hydroxy-phenyl)-benzofuran-3-one
5,7-dihydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid
5,7-dihydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid ethyl ester
4,5,7-trihydroxy-3-(4-hydroxy-phenyl)-coumarin
5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on
