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Methyl-Cantharidimide (MCA) is a derivative of cantharidin which has potential anticancer activity, while it's Molecular Formula is C11H15NO3.
The CAS number of cantharidin methylimide is 76970-78-0.
More information of cantharidin methylimide 76970-78-0 are:
|
Synonyms |
4,7-Epoxy-1H-isoindole-1,3(2H)-dione,hexahydro-2,3a,7a-trimethyl-, (3aa,4b,7b,7aa)- |
|
CAS Number |
76970-78-0 |
|
Molecular Formula |
C11H15NO3 |
|
Molecular Weight |
209.245 |
|
Density |
1.275g/cm3 |
|
Boiling Point |
329.2°C at 760 mmHg |
|
Flash Point |
152.9°C |
|
PSA |
46.61000 |
|
LogP |
0.49670 |
Methyl-cantharidimide inhibits the proliferation of HCC cells by regulating cell cycle arrest, indicating that methyl-cantharidimide has a cytotoxic effect on HCC cells via inducing cell cycle arrest. Some studies have investigated the efficacy of methyl-cantharidimide (MCA), a cantharidin (CTD) analog, as an anticancer drug, in cancer cells overexpressing either ABCB1 or ABCG2 transporters and in cisplatin-resistant cancer cells.
InChI:InChI=1/C11H15NO3/c1-10-6-4-5-7(15-6)11(10,2)9(14)12(3)8(10)13/h6-7H,4-5H2,1-3H3/t6-,7+,10+,11-
Articles related to cantharidin methylimide:
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Article |
Source |
| Methyl-cantharidimide (MCA) can induce apoptosis by activating UNC5B-Netrin-1-DAPK pathway in hepatocellular carcinoma |
Yi-Dong Li; Yong Mao; Xing-Duo Dong; Zi-Ning Lei; Yuqi Yang; Lizhu Lin; Dong-Hua Yang; Zhe-Sheng Chen Cancer Res (2022) 82 (12_Supplement): 360. |
| Effects of methyl cantharidimide tablets on urinary protein and enzymes in Beagle dogs |
Luo XQ, Yang X, Hu R, Huang WT, Lan B, Tu RX, Liu JY Materia Medica, 01 Nov 2014, 39(22):4426-4429 |
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